His research interests cover the
following fields: Structure and function of the nucleus and Inositide-dependet
Signalling. He has discovered the
existence of the nuclear signalling pathway
via inositol lipid cycle and he is
internationally recognised in the field of inositide signalling as “one the fathers of nuclear inositide signalling”
for his seminal work in this issue. In particular since the last years
his main interest is the study of the nuclear localisation and signalling
activity of polyphosphoinositides. Namely he has furtherd the role of this
signalling pathway in the nucleus during myogenic differentiation, giving new
insight to its role in myotonic dystrophies, as well as during haemopoietic
differentiation, envisaging the pathophysiological
significance of nuclear phosphoinositide signalling in Myelodysplactic
Molecular biology techniques, stem cells manipulation, DNA, RNA analysis
Mainly ultrastructural tecniques and any type of imaging
-Follo MY, Pellagatti A, Armstrong RN, Ratti S, Mongiorgi S, De Fanti S,
Bochicchio MT, Russo D, Gobbi M, Miglino M, Parisi S, Martinelli G, Cavo M,
Luiselli D, McCubrey JA, Suh PG, Manzoli L, Boultwood J, Finelli C, Cocco L.
Response of high-risk MDS to azacitidine and lenalidomide is impacted by baseline
and acquired mutations in a cluster of three inositide-specific genes. Leukemia.
-Piazzi M, Blalock WL, Bavelloni A, Faenza I, Raffini M, Tagliavini F, Manzoli
L, Cocco L. PI-PLCβ1b affects Akt activation, cyclin E expression, and caspase
cleavage, promoting cell survival in pro-B-lymphoblastic cells exposed to
oxidative stress. FASEB J. 2015 Apr;29(4):1383-94
- McCubrey JA, Steelman LS, Bertrand FE, Davis NM, Abrams SL, Montalto G,
D'Assoro AB, Libra M, Nicoletti F, Maestro R, Basecke J, Cocco L, Cervello M,
Martelli AM. Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and
leukemogenesis: opportunities for therapeutic intervention. Leukemia. 2014
-Piazzi M, Blalock WL, Bavelloni A, Faenza I, D'Angelo A, Maraldi NM, Cocco L.
Phosphoinositide-specific phospholipase C β 1b (PI-PLCβ1b) interactome: affinity
purification-mass spectrometry analysis of PI-PLCβ1b with nuclear protein. Mol
Cell Proteomics. 2013 Aug;12(8):2220-35.
-Follo MY, Mongiorgi S, Clissa C, Paolini S, Martinelli G, Martelli AM,
Fioravanti G, Manzoli L, Finelli C, Cocco L. Activation of nuclear inositide
signalling pathways during erythropoietin therapy in low-risk MDS patients.
Leukemia. 2012 Dec;26(12):2474-82.
University Politehnica Bucharest