Biomechanics and structural properties of materials, especially vertebrate skeletal tissues
Functional morphology and evolution of feeding in vertebrates, particularly fishes
Collaborative, reciprocal approaches, integrating science, technology, engineering, art and design
Integrating science, experience and technology as a teaching/presentation methodology
Our group is interested in comparative and evolutionary perspectives on vertebrate skeletal tissues, particularly bone and cartilage. We work in a department with a variety of imaging and materials science tools, useful for characterizing the structure and mechanics of tissues.
We are interested in developing and integrating more tools for cell structure, biology and mechanobiology work, particularly in the study of chondrocytes. We would be particularly interested in collaborating with groups near coastal areas AND with access to high-pressure freezing facilities, since we are interested in studying fresh tissues from fishes.
Seidel, R, A Roschger, L Li, JJ Bizzarro, Q Zhang, J Yin, T Yang, JC Weaver, P Fratzl, P Roschger & MN Dean (2019) Mechanical properties of stingray tesserae: High-resolution correlative analysis of mineral density and indentation moduli in tessellated cartilage. Acta Biomaterialia. In press
Ofer, L, MN Dean, P Zaslansky, S Kult, Y Shwartz, J Zaretsky, S Griess-Fishheimer, E Monsonego- Ornan, E Zelzer & R Shahar (2019) A novel non-osteocytic regulatory mechanism of bone modeling. PLoS Biology. 17(2): e3000140. (DOI: https://doi. org/10.1371/journal.pbio.3000140)
Knoetel D, R Seidel, S Prohaska, MN Dean & D Baum (2017) Automated segmentation of complex patterns in biological tissues: Lessons from stingray tesselated cartilage. PLoS ONE. 12(12): e0188018. (DOI: 10.1371/journal.pone.0188018)
Seidel R, M Blumer, E-J, Pechriggl, K Lyons, BK Hall, P Fratzl, JC Weaver & MN Dean (2017) Cartilage or bone? Collagens in the skeleton of “cartilaginous” fishes answer an old question. Journal of Structural Biology. 200(1): 54-71. (DOI: 10.1016/j.jsb.2017.09.005)
Currey JD, MN Dean, R Shahar (2017) Revisiting the links between bone remodeling and osteocytes: insights from across phyla. Biological Reviews. 92: 1702–1719. (DOI: 10.1111/brv.12302)