ANDRES VICENTE

ANDRES VICENTE Country: Spain
Laboratory webpage
E-mail: vandres@cnic.es

Participation in Working Groups

  • WG3 - New methodologies to study mechanobiology of cells and tissues
  • WG4 - Mechanobiological principles of rare and common diseases

Research Interests

Our research addresses the role of lamin A in the regulation of pathophysiological processes and the mechanisms that accelerate cardiovascular disease and aging in patients with Hutchinson-Gilford progeria syndrome (HGPS), a rare genetic disease caused by progerin, a mutant form of lamin A which is also expressed at low level in tissues from non-HGPS subjects. Our experimental strategy involves a multifaceted approach that combines in vitro, cellular, animal and human studies and a variety of technologies, including mouse genetic engineering, proteomics, transcriptomics, FRET, confocal microscopy, in vivo invasive and non-invasive imaging.

Technologies offered to other EuroCellNet participants

Molecular and cellular techniques and methodologies to study cardiovascylar disease using cellular and animal models and analysis of human samples.

Technologies sought from other EuroCellNet participants

Single cells genomics.

Publications

Hamczyk MR, Villa-Bellosta R, Quesada V, Gonzalo P, Vidak S, Nevado RM, Andrés-Manzano MJ, Misteli T, López-Otín C*, Andrés V*. Progerin accelerates atherosclerosis by inducing endoplasmic reticulum stress in vascular smooth muscle cells. EMBO Mol Med 11(4).pii:e9736. doi: 10.15252/emmm.201809736 (2019).

Hamczyk MR, Villa-Bellosta R, Gonzalo P, Andrés-Manzano MJ, Nogales P, Bentzon JF, López-Otín C, Andrés V. Vascular smooth muscle-specific progerin expression accelerates atherosclerosis and death in a mouse model of Hutchinson-Gilford progeria syndrome. Circulation 138:283-286 (2018)

Fernández-Alvira JM, Fuster V*, Dorado B, Soberón N, Flores I, Gallardo M, Pocock S, Blasco MA & Andrés V*. Short telomere load, telomere length and subclinical atherosclerosis in the PESA study. J Am Coll Cardiol 67:2467-2476 (2016)

Chèvre R, González-Granado JM, Megens RTA, Sreeramkumar V, Silvestre-Roig C, Molina-Sánchez P, Weber C, Soehnlein O, Hidalgo A*, Andrés V*. High-resolution imaging of intravascular atherogenic inflammation in live mice. Circ Res 114:770-779 (2014) (Issue cover)

Villa-Bellosta R, Rivera-Torres J, Osorio FG, Acín-Pérez R, Enriquez JA, López-Otín C, Andrés V. Defective extracellular pyrophosphate metabolism promotes vascular calcification in a mouse model of Hutchinson-Gilford progeria syndrome that is ameliorated on pyrophosphate treatment. Circulation 127:2442-2451 (2013)