Lammerding Jan

Lammerding Jan Country: United States
Laboratory webpage
E-mail: jan.lammerding@cornell.edu

Participation in Working Groups

  • WG1 - Biophysics of cell and tissue structure
  • WG3 - New methodologies to study mechanobiology of cells and tissues
  • WG4 - Mechanobiological principles of rare and common diseases

Research Interests

Lamin intermediate filament proteins. Nuclear envelope. Mechanobiology.

Cell migration. Muscular dystrophy. Cardiomyopathies. Nuclear enveloppathies.

Technologies offered to other EuroCellNet participants

We have developed a number of microfluidic and micromanipulation tools to measure subcellular biomechanics and to study nuclear mechanobiology.

Technologies sought from other EuroCellNet participants

Applications of nuclear mechanobiology.

Cancer cell migration and metastasis.

Disease mechanism of laminopathies.

Novel technological approaches.

Graduate student and postdoctoral fellow candidates.

Publications

Denais CM, Gilbert RM, Isermann P, Mcgregor AL, te Lindert M, Weigelin B, Davidson PM, Friedl P, Wolf K, Lammerding J. (2016). Nuclear envelope rupture and repair during cancer cell migration. Science. 352(6283): 353-358

Ho CY, Jaalouk DE, Vartiainen MK, Lammerding J. (2013). Lamin A/C and emerin regulate MKL1/SRF activity by modulating actin dynamics. Nature. 497(7450):507-11

Zwerger M, Jaalouk DE, Lombardi ML, Isermann P, Mauermann M, Dialynas G, Herrmann H, Wallrath LL, Lammerding J. (2013). Myopathic lamin mutations impair nuclear stability in cells and tissue and disrupt nucleo-cytoskeletal coupling. Hum Mol Gen. 22(12):2335-49. doi: 10.1093/hmg/ddt079.

Kirby TJ. Lammerding J. (2018). Emerging views of the nucleus as a cellular mechanosensor. Nat Cell Biol. 20(4): 373-381

Davidson PM, Sliz J, Isermann P, Denais C, Lammerding J. (2015). Design of a microfluidic device to quantify dynamic intra-nuclear deformation during cell migration through confining environments. Integr Biol. 7:1534-1546