Lamin intermediate filament proteins. Nuclear envelope. Mechanobiology.
Cell migration. Muscular dystrophy. Cardiomyopathies. Nuclear enveloppathies.
We have developed a number of microfluidic and micromanipulation tools to measure subcellular biomechanics and to study nuclear mechanobiology.
Applications of nuclear mechanobiology.
Cancer cell migration and metastasis.
Disease mechanism of laminopathies.
Novel technological approaches.
Graduate student and postdoctoral fellow candidates.
Denais CM, Gilbert RM, Isermann P, Mcgregor AL, te Lindert M, Weigelin B, Davidson PM, Friedl P, Wolf K, Lammerding J. (2016). Nuclear envelope rupture and repair during cancer cell migration. Science. 352(6283): 353-358
Ho CY, Jaalouk DE, Vartiainen MK, Lammerding J. (2013). Lamin A/C and emerin regulate MKL1/SRF activity by modulating actin dynamics. Nature. 497(7450):507-11
Zwerger M, Jaalouk DE, Lombardi ML, Isermann P, Mauermann M, Dialynas G, Herrmann H, Wallrath LL, Lammerding J. (2013). Myopathic lamin mutations impair nuclear stability in cells and tissue and disrupt nucleo-cytoskeletal coupling. Hum Mol Gen. 22(12):2335-49. doi: 10.1093/hmg/ddt079.
Kirby TJ. Lammerding J. (2018). Emerging views of the nucleus as a cellular mechanosensor. Nat Cell Biol. 20(4): 373-381
Davidson PM, Sliz J, Isermann P, Denais C, Lammerding J. (2015). Design of a microfluidic device to quantify dynamic intra-nuclear deformation during cell migration through confining environments. Integr Biol. 7:1534-1546
9-11 September 2019, Trnava, Slovakia