I study the effect of hemodynamic stress, such as hypertension, in blood vessels. In particular, I am interested in the role of Notch signaling in Vimentin mechanotransduction during shear stress and strain, in both endothelial and vascular smooth muscle cells. What I am passionate about is to understand the mechanisms underlying pathologies. In how to guide our search for knowledge to find real solutions for the millions around the world who suffer from various diseases.
Zebrafish work, confocal microscopy, Co-Immunoprecipitation, biotinylation IPs, Phospholayer assay (luciferase reporter in co-culture).
Techniques to study mechanobiology: imaging, 3D printing, bioengineering.
I just started my Ph.D. on March 19th 2019 so I have currently only one publication:
Driessen, R., Stassen, O., Sjöqvist, M., Suarez Rodriguez, F., Grolleman, J., Bouten, C., & Sahlgren, C. (2018). Shear stress induces expression, intracellular reorganization and enhanced Notch activation potential of Jagged1. Integrative Biology, 719-726.
We have send also a second publication which we hope will be publish this year, title:
Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress. Nicole C.A. van Engeland #, Freddy Suarez Rodriguez # Adolfo Rivero-Müller, Tommaso Ristori, Camille L. Duran5, Marika Sjöqvist, Oscar M.J.A. Stassen, Daniel Antfolk, Rob Driessen, Saku Ruohonen, Suvi T. Ruohonen, Salla Nuutinen, Eriika Savontaus, Sandra Loerakker, Kayla J. Bayless, Carlijn V.C. Bouten, John E. Eriksson, Cecilia M. Sahlgren
# Equal contribution
25–30 May 2020, Spetses Island, Greece