Redowicz Maria Jolanta

Redowicz Maria Jolanta Country: Poland
Laboratory webpage
E-mail: j.redowicz@nencki.gov.pl

Participation in Working Groups

  • WG1 - Biophysics of cell and tissue structure
  • WG2 - Structural analysis of biomolecules involved in mechanobiology
  • WG3 - New methodologies to study mechanobiology of cells and tissues
  • WG4 - Mechanobiological principles of rare and common diseases

Research Interests

Cell motility and the actin cytoskeleton; unconventional myosins in health and disesase; muscle biology and pathology; nuclear functions of unconventional myosin VI

Technologies offered to other EuroCellNet participants

Primary culture myoblasts, myofiber contraction analysis, numerous biochemical and cell biology techniques to assess protein structure-function relationship in vitro and in vivo

Technologies sought from other EuroCellNet participants

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Publications

1. Schneider G., Nieznański K., Jóźwiak J., Słomnicki Ł.P., Rędowicz M.J., Filipek A. (2010) Tubulin binding protein, CacyBP/SIP, induces actin polymerization and may link actin and tubulin cytoskeletons. BBA - Molecular Cell Research, 1803, 1308-1317.
2. Majewski Ł., Sobczak M., Wasik A., Skowronek K., Rędowicz M.J. (2011) Myosin VI in PC12 cells plays important roles in cell migration and proliferation but not in catecholamine secretion. J. Muscle Res. Cell Motil. 32 , 291-302.
3. Jóźwiak J., Rzhepetskyy Y., Sobczak M., Kocik E., Skórzewski R., Kłopocka W., Rędowicz M.J.
4. Majewski Ł., Sobczak M., Jóźwiak J, Havrylov S., Rędowicz M.J. (2012) Dock7: A GEF for Rho-family GTPases and a novel myosin VI binding partner in neuronal PC12 cells. Biochem Cell Biol 90, 565-574.
5. Karolczak J., Sobczak M., Majewski Ł., Yeghiazaryan M., Jakubiec-Puka A., Ehler E., Sławińska U., Wilczyński G., Rędowicz M.J. (2013) Myosin VI in skeletal muscle: its distribution in the sarcomere, neuromuscular junction and muscle nuclei. Histochem Cell Biol, 139:873-885.
6. J Karolczak, S Weis, E Ehler, B Kierdaszuk, M Berdyński, C Żekanowski, AM Kamińska, MJ Rędowicz (2014) Myosin VI localization and expression in striated muscle pathology. Anat Rec 297, 1706-1713
7. I Pavlyk, Y Rzhepetskyy, AK Jagielski, J. Drozak, A. Wasik, G. Pereverzieva, M. Olchowik, LA. Kunz-Schughart, O Stasyk, MJ Redowicz (2015) Arginine deprivation affects glioblastoma cell adhesion, invasiveness and actin cytoskeleton organization by impairment of β-actin arginylation. Amino Acids 47, 199-212.
8. Karolczak J, Pavlyk I, Majewski Ł, Sobczak M, Niewiadomski P, Rzhepetskyy, Sikorska A, Nowak N, Pomorski P, Prószyński T, Ehler E, Rędowicz MJ. (2015) Involvement of unconventional myosin VI in myoblast function and myotube formation. Histochem Cell Biol 144:21-38
9. M. Sobczak, V. Chumak, P. Pomorski, E. Wojtera, L. Majewski, J. Nowak, J. Yamauchi, MJ. Redowicz (2016) Interaction of myosin VI and its binding partner DOCK7 plays an important role in NGF-stimulated protrusion formation in PC12 cells. BBA - Molecular Cell Research, 1863, 1589-1600.
10. Majewski L, Nowak J, Sobczak M, Karatsai O,Havrylov S, Lenartowski R, Suszek M, Lenartowska M, Rędowicz M.J. (2018) Myosin VI in the nucleus of neurosecretory PC12 cells: Stimulation-dependent nuclear translocation and interaction with nuclear proteins. Nucleus 9, 125-