Our research is focused on the fundamental molecular mechanisms, that guide cell fate and cell organization in stem cell differentiation, tissue formation and in disease such as cancer. Together with collaborators we utilize such knowledge to develop material-based medical technologies to control these mechanisms in regenerative and cancer therapies. Coordination of cells through molecular cell signaling pathways is crucial for the formation of functional tissues and signaling is often deregulated in diseases such as cancer, allowing cells to acquire abnormal functions and pathological remodeling of tissue architecture. The physical, mechanical and chemical stimuli of the microenvironment also influence cell signaling and cell fate decisions during development and disease progression.
The Cell Fate Lab tries to find answers to 3 key questions:
How are signaling mechanisms making cell fate decisions based on input from cell autonomous mechanisms and the environment?
How does these mechanisms influence stem cell differentiation and how do deregulated mechanisms link to disease?
How can cell signaling be modulated for therapeutical purposes in order to control cell fate in cancer and regenerative therapy?
Rob C.H Driessen, Oscar M.J.A Stassen, Marika Sjöqvist, Freddy S.F. Rodriguez, Janine Grolleman, Carlijn C.V. Bouten, Cecilia M. Sahlgren. (2018) Shear stress induces expression, intracellular re-organization and enhanced Notch activation potential of Jagged1. Integrative Biology doi: 10.1039/c8ib00036k.
Nicole C.A. van Engeland, Andreas M.A.O. Pollet, Carlijn V.C. Bouten, Oscar M.J.A. Stassen, Cecilia M. Sahlgren. (2018) A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions Lab on a Chip doi: 10.1039/c8lc00286
Sandra Loerakker, Oscar M.J.A. Stassen, Fleur ter Huurne, Marcelo Boareto, Carlijn V.C. Bouten, Cecilia M. Sahlgren. (2018) Mechanosensitivity of Jagged–Notch signalling can induce a switch-type behavior in vascular homeostasis. PNAS doi: 10.1073/pnas.1715277115
Laura A. Tiemeijer, Jean-Philippe M. S. Frimat, Oscar M. J. A. Stassen, Carliijn. V. C. Bouten, and Cecilia M. Sahlgren. (2018) Spatial patterning of the Notch ligand Dll4 to control endothelial sprouting in vitro. Scientific Reports doi: 10.1038/s41598-018-24646-y
Daniel Antfolk, Marika Sjoqvist, Fang Cheng, Kimmo Isonniemi, Camille L. Duran, Adolfo Rivero-Muller, Christian Antila , Rasmus Niemi , Sebastian Landor, Carlijn C.V. Bouten, Kayla J. Bayless, John E. Eriksson, Cecilia Maria Sahlgren. (2017) Selective regulation of Notch ligands during angiogenesis is mediated by vimentin PNAS doi: 10.1073/pnas.1703057114.