I am studying the role of intestinal epithelia in development of digestive disorders as well as the importance of epithelial products as biomarkers.
Experience in clinical and translational research in the field of digestive diseases with a focus on transgenic mouse models and rare diseases.
Gross A, Pack LA, Schacht GM, Kant S, Krusche CA, Meir M, Schlegel N, Ungewiss H, Waschke J, Preisinger C, Guldiken N, Boor P, Heuser A, Sellge G, Trautwein C, Leube RE, Strnad P. (2018) The desmosomal cadherin desmoglein 2, but not desmocollin 2, protects from epithelial injury. Mucosal Immunol 11:1630-1639.
Guldiken N, Kobazi Ensari G, Lahiri P, Couchy G, Preisinger C, Liedtke C, Zimmermann HW, Ziol M, Boor P, Zucman-Rossi J, Trautwein C, Strnad P. (2016) Keratin 23 is a stress-inducible marker of mouse and human ductular reaction in liver disease.J Hepatol 65:552-59.
Chen Y, Guldiken N, Spurny M, Haybaeck J, Pollheimer MJ, Fickert P, Gassler N, Jeon MK, Trautwein C, Strnad P. (2015) Loss of keratin 19 favours the development of cholestatic liver disease via decreased Notch-mediated ductular reaction. J Pathol 237:343-54.
Guldiken N, Zhou Q, Kucukoglu O, Rehm M, Levada K, Gross A, Kwan R, James LP, Trautwein C, Omary MB, Strnad P. (2015) Human keratin 8 variants promote mouse acetaminophen hepatotoxicity coupled with JNK activation and protein adduct formation. Hepatology 62:876-86.
Kucukoglu O, Guldiken N, Chen Y, Usachov V, El-Heliebi A, Haybaeck J, Denk H, Trautwein C, Strnad P. (2014) High-fat diet triggers Mallory-Denk body formation via misfolding and crosslinking of excess keratin 8. Hepatology 60:169-178
25–30 May 2020, Spetses Island, Greece