My research project focusses on keratins K5/K14 and K8/K18. In particular I study the assembly of them by EM, cryo EM and chemical cross linking mass spectrometry. The general goal is to build/improve the 3D model of keratins. This includes dimers, but also other assembly stages. In addition, the effect of mutations will be studied by XL-MS. Moreover, X-ray crystallography on fragment of keratins will be attempted.
At the moment, none. Although, I will gain expertise in (cryo) EM and XL-MS.
training about XL-MS. And information about effect of keratin mutations on cell mechanics.