Country: United Kingdom
Structure function links within the mammalian nucleus and how defects in these links result in pathology, eg cancer. I am especially interested in mechanisms of establishing nuclear compartments and specifically functional sites or domains, such as transcription factories. How/if such sites are coordinated by the functions of the nucleoskeleton - lamin proteons - if also a key interest.
High end luve cell imaging.
Live imaging options for super resolution microscopy.
*Tang CW, Maya-Mendoza A, Martin C, Zeng K, Chen S, Feret D, Wilson SA, Jackson DA (2008). The integrity of a lamin B1-dependent nucleoskeleton is a fundamental determinant of RNA synthesis in human cells. J Cell Sci 121, 1014-1024.
*Martin C, Chen S, Maya-Mendoza A, Lovric J, Sims PFG, Jackson DA. (2009). Lamin B1 maintains the functional plasticity of nucleoli. J Cell Sci 122, 1551-1562.
*Chen S§, Maya-Mendoza A§, Zeng K, Tang CW, Sims PFG, Lovric J, Jackson DA. (2009). Interaction with Checkpoint Kinase 1 Modulates the Recruitment of Nucleophosmin to Chromatin. J Proteome Res 8, 4693-4704.
*Chen S, Martin C, Maya-Mendoza A, Tang CW, Lovrić J, Sims PFG, Jackson DA. (2009). Reduced expression of lamin A/C results in modified cell signalling and metabolism coupled with changes in expression of structural proteins. J Proteome Res 8, 5196-5211.
Maya-Mendoza A, Olivares-Chauvet P, Shaw A and Jackson DA. (2010). S phase progression in mammalian cells is dictated by the genetic continuity of DNA foci. PLoS Genet 4, e1000900.
25–30 May 2020, Spetses Island, Greece