I work on the interplay between mechanical forces and Notch signalling as determinants of cell and tissue fate.
To study this we use techniques such as microcontact printing, organs on chip, computational models and molecular biology techniques.
I'm interested in using omics approaches on the controlled culture systems we have.
Spatial patterning of the Notch ligand Dll4 controls endothelial sprouting in vitro. - Tiemeijer LA, Frimat JP, Stassen OMJA, Bouten CVC, Sahlgren CM
Mechanosensitivity of Jagged-Notch signaling can induce a switch-type behavior in vascular homeostasis. - Loerakker S, Stassen OMJA, Ter Huurne FM, Boareto M, Bouten CVC, Sahlgren CM.
A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions. - van Engeland NCA, Pollet AMAO, den Toonder JMJ, Bouten CVC, Stassen OMJA, Sahlgren CM.
The Mechanical Contribution of Vimentin to Cellular Stress Generation. - van Loosdregt IAEW, Weissenberger G, van Maris MPFHL, Oomens CWJ, Loerakker S, Stassen OMJA, Bouten CVC.
GFAPδ/GFAPα ratio directs astrocytoma gene expression towards a more malignant profile. - Stassen OMJA, van Bodegraven EJ, Giuliani F, Moeton M, Kanski R, Sluijs JA, van Strien ME, Kamphuis W, Robe PAJ, Hol EM.