Laly Aguedo Ana Catarina

Laly Aguedo Ana Catarina Country: United Kingdom
Laboratory webpage
E-mail: a.c.lalyaguedo@qmul.ac.uk

Participation in Working Groups

  • WG2 - Structural analysis of biomolecules involved in mechanobiology
  • WG3 - New methodologies to study mechanobiology of cells and tissues
  • WG4 - Mechanobiological principles of rare and common diseases

Research Interests

My main research interests are trying to understand the exact mechanisms that regulate keratin cytoskeleton organisation and how keratin is exactly involve in cellular mechanotrasnduction. This will hopefully help us better understand the importance of this intermediate filament into skin structure stability. Apart from keratin, I am also interested in Lamin A/C and EGFR signalling.

Technologies offered to other EuroCellNet participants

During the last two years of my PhD I've been mainly involved in the development and optimisation of polyacrylamide gels, immunostaining, confocal imaging and western blotting. 

Technologies sought from other EuroCellNet participants

I would like to learn more about high resolution techniques. Apart from imaging, I would also like to have a better insight into the translation of mechanobiology study to clinical practise. Finally, it would be on my best interest to learn more about recent techniques capable of measuring specific cellular physical interactions at a molecular scale.  

Publications

Mechanical Regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity, Alberto Elosegui-Artola et. Al.

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation, Swift et. al.

Keratins as the main component for the mechanical integrity of keratinocytes, Ramms et al.

Cytoskeleton in motion: the dynamics of keratin intermediate filaments in epithelia, Windoffer et. al.

Tissue stiffening promotes keratinocyte proliferation through activation of epidermal growth factor signaling, Kenny et. al.