Haagdorens Michel

Country: Belgium
E-mail: michelhaagdorens@gmail.com

Participation in Working Groups

  • WG1 - Biophysics of cell and tissue structure

Research Interests

As a rsearcher, my focus lies within corneal tissue engineering. Our lab has built a vast reputation within the development of cellularized biomaterials as a substitute material for conventional tissue grafts within ocular surgeries. During my PhD, I have focused on the development of collagen hydrogels covered by corneal epithelial stem cells for the treatment of orphan corneal diseases. Other topics of interest of our lab are the generation of the tissue engineered ocular conjunctiva, full thickness biocorneas and biomimetic ocular endothelium. The main topics of my research interests are: 3D cell imaging, whole mount graft imaging, cell-cell interaction, tissue engineering, live cell imaging and biomaterials.

Technologies offered to other EuroCellNet participants

During my research I have gained experience and skills in physical and optical characterization of biomaterials, stem cell isolation, stem cell cultivation and live cell imaging. Due to composite graft post-processing I have gained especial interest in immunohistochemistry, qPCR, Electron microscopy and karyotyping. Furthermore, I have built an exptensive network with centers that perform chemical and physical characterization of (composite) biomaterials as well as a specific Belgian center of (live cell imaging) microscopy. We would be happy to host other researchers to share our knowledge on stem cell isolation, stem cell cultivation, immunostaining, live cell imaging, composite graft generation, GMP-grade research and collagen hydrogels.

Technologies sought from other EuroCellNet participants

By joining the EU cost action, I hope to share knowledge on stem cell cultivation, stem cell fate an stem cell differentiation. I have built expertise on whole-mount and cryosectioned immunofluorescent tissue stainings. I believe it could be of greatest value to join this cost action and share our knowledge, but also gain expertise of other partners with specific insight in (Live) 3D imaging, live cell imaging and 3D electronmicroscopy.

Publications

As a young scientist I have only 3 publications published within the domain of tissue engineering and cell imaging. I have gathered more publications throughout my scientific carreer, however, these publications are strictly clinical and are not of much importance for the COST action. Neverthless, as a young scientist who has only been working within this domain for a couple of years, I have several interesting manuscripts that have been submitted to several scientific journals. As these manuscripts have yet to be accepted for publication, I have not included them in this list.

Jangamreddy JR, Haagdorens M, et al., Short Peptide Analogs as Alternatives to Collagen in Pro-Regenerative Corneal Implants. Acta Biomaterialia, 2018. doi: 10.1016/j.actbio.2018.01.011.

Haagdorens M, Behaegel J, et al., A method for quantifying limbal stem cell niches using OCT imaging. Br J Ophthalmol, 2017. 101 (9): 1250-5.

Haagdorens M, Van Acker SI, et al., Limbal Stem Cell Deficiency: Current Treatment Options and Emerging Therapies. Stem Cells International, 2016. Article ID 9798374, 22 pages.