I am interested in chromatin architecture. Currently we are investigating the possible role of single strand breaks and RNA/DNA hybrids in transciption regulation. Furthermore we are investigating the effect of histone destabilization to chromatin structure and function.
Knowledge using Confocal and Laser Scanning Microscopy. We have developed a nucleosome elution assay in our lab, recently published article below. DNA combing.
We have no access to superresolution microscopes yet.
Nucleosome stability measured in situ by automated quantitative imaging - (Imre L, Simándi Z, Horváth A, Fenyőfalvi G, Nánási P, Niaki EF, Hegedüs É, Bacsó Z, Weyemi U, Mauser R, Ausio J, Jeltsch A, Bonner W, Nagy L, Kimura H, Szabó G. - Scientific Reports 2017.