Gregor Martin

Gregor Martin Country: Czech Republic
Laboratory webpage
E-mail: martin.gregor@img.cas.cz

Participation in Working Groups

  • WG1 - Biophysics of cell and tissue structure
  • WG3 - New methodologies to study mechanobiology of cells and tissues
  • WG4 - Mechanobiological principles of rare and common diseases

Research Interests

The main research focus has been centered for several past years around understanding cytoskeleton organization and dynamics, cell adhesion and cell signaling. In particular I am interested in plectin-dependent regulation of the actin and intermediate filament cytoskeleton, adhesion mediated signalling and cell motility using molecular cell biology in various cell types derived from transgenic mice models. Currently I am developing mouse models for studying disease-related, cell biological and molecular aspects of cytoskeletal and other proteins in digestive organs. I am applying my research to the understanding of liver fibrosis, inflammatory bowel diseases and cancerogenesis.

Technologies offered to other EuroCellNet participants

CRISPR/Cas9 targeting

Technologies sought from other EuroCellNet participants

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Publications

Brauer R., Tureckova J., Kanchev I., Khoylou M., Skarda J., Prochazka J., Spoutil F., Beck I.M., Zbodakova O., Kasparek P., Korinek V., Chalupsky K., Karhu T., Herzig K.H., Hajduch M., Gregor M.*, Sedlacek R.*: MMP-19 deficiency causes aggravation of colitis due to defects in innate immune cell function. Mucosal Immunol., 9:974-85, 2016.

Song J.-G., Kostan J., Drepper F., Knapp B., de Almeida Ribeiro Jr E., Konarev P.V., Grishkovskaya I., Wiche G., Gregor M., Svergun D.I., Warscheid B., Djinović-Carugo K.: Structural insights into Ca2+/calmodulin regulation of plectin 1a - integrin β4 interaction in hemidesmosomes. Structure, 23:558-70, 2015.

Gregor M.*, Osmanagic-Myers S.*, Burgstaller G., Wolfram M., Fischer I., Walko G., Resch G.P., Jörgl A., Herrmann H., Wiche G.: Mechanosensing through focal adhesion-anchored intermediate filaments. FASEB J., 28:715-29, 2014.

Burgstaller G.*, Gregor M.*, Winter L., Wiche G.: Keeping the vimentin network under control: cell–matrix adhesion-associated plectin 1f affects cell shape and polarity of fibroblasts. Mol. Biol. Cell, 21:3362–3375, 2010.

Osmanagic-Myers S.*, Gregor M.*, Walko G.*, Burgstaller G., Reipert S., Wiche G.: Plectin-controlled keratin cytoarchitecture affects MAP kinases involved in cellular stress response and migration. J. Cell Biol. 174: 557-68, 2006.

News

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