Lattanzi Giovanna

Country: Italy
Laboratory webpage
E-mail: giovanna.lattanzi@cnr.it

Participation in Working Groups

  • WG4 - Mechanobiological principles of rare and common diseases

Research Interests

Lamins and nuclear envelope biology, laminopathies.

Technologies offered to other EuroCellNet participants

Primary Cell Clutures

Cell biology studies

Confocal and fluorescence microscopy

Electron and immunoelectron microscopy (TEM and SEM)

Wester blot

Co-IP. Proximity ligation assay (PLA) and other PPI studies

qRT-PCR and in situ qRT-PCR

Technologies sought from other EuroCellNet participants

wide genome and proteomic screening

animal models

Publications


1: Angori S, Capanni C, Faulkner G, Bean C, Boriani G, Lattanzi G, Cenni V.
Emery-Dreifuss Muscular Dystrophy-Associated Mutant Forms of Lamin A Recruit the
Stress Responsive Protein Ankrd2 into the Nucleus, Affecting the Cellular
Response to Oxidative Stress. Cell Physiol Biochem. 2017 May 25;42(1):169-184.
doi: 10.1159/000477309. [Epub ahead of print] PubMed PMID: 28531892.

2: Evangelisti C, Cenni V, Lattanzi G. Potential therapeutic effects of the MTOR
inhibitors for preventing ageing and progeria-related disorders. Br J Clin
Pharmacol. 2016 Nov;82(5):1229-1244. doi: 10.1111/bcp.12928. Epub 2016 May 18.
Review. PubMed PMID: 26952863; PubMed Central PMCID: PMC5061804.

3: Pellegrini C, Columbaro M, Capanni C, D'Apice MR, Cavallo C, Murdocca M,
Lattanzi G, Squarzoni S. All-trans retinoic acid and rapamycin normalize
Hutchinson Gilford progeria fibroblast phenotype. Oncotarget. 2015 Oct
6;6(30):29914-28. doi: 10.18632/oncotarget.4939. PubMed PMID: 26359359; PubMed
Central PMCID: PMC4745772.

4: Evangelisti C, Bernasconi P, Cavalcante P, Cappelletti C, D'Apice MR, Sbraccia
P, Novelli G, Prencipe S, Lemma S, Baldini N, Avnet S, Squarzoni S, Martelli AM,
Lattanzi G. Modulation of TGFbeta 2 levels by lamin A in U2-OS osteoblast-like
cells: understanding the osteolytic process triggered by altered lamins.
Oncotarget. 2015 Apr 10;6(10):7424-37. PubMed PMID: 25823658; PubMed Central
PMCID: PMC4480690.

5: Camozzi D, Capanni C, Cenni V, Mattioli E, Columbaro M, Squarzoni S, Lattanzi
G. Diverse lamin-dependent mechanisms interact to control chromatin dynamics.
Focus on laminopathies. Nucleus. 2014 Sep-Oct;5(5):427-40. doi:
10.4161/nucl.36289. Review. PubMed PMID: 25482195; PubMed Central PMCID:
PMC4164485.

6: Meinke P, Mattioli E, Haque F, Antoku S, Columbaro M, Straatman KR, Worman HJ,
Gundersen GG, Lattanzi G, Wehnert M, Shackleton S. Muscular dystrophy-associated
SUN1 and SUN2 variants disrupt nuclear-cytoskeletal connections and myonuclear
organization. PLoS Genet. 2014 Sep 11;10(9):e1004605. doi:
10.1371/journal.pgen.1004605. eCollection 2014 Sep. PubMed PMID: 25210889; PubMed
Central PMCID: PMC4161305.

7: Lattanzi G, Ortolani M, Columbaro M, Prencipe S, Mattioli E, Lanzarini C,
Maraldi NM, Cenni V, Garagnani P, Salvioli S, Storci G, Bonafè M, Capanni C,
Franceschi C. Lamins are rapamycin targets that impact human longevity: a study
in centenarians. J Cell Sci. 2014 Jan 1;127(Pt 1):147-57. doi:
10.1242/jcs.133983. Epub 2013 Oct 23. PubMed PMID: 24155329.

8: Mattioli E, Columbaro M, Capanni C, Maraldi NM, Cenni V, Scotlandi K, Marino
MT, Merlini L, Squarzoni S, Lattanzi G. Prelamin A-mediated recruitment of SUN1
to the nuclear envelope directs nuclear positioning in human muscle. Cell Death
Differ. 2011 Aug;18(8):1305-15. doi: 10.1038/cdd.2010.183. Epub 2011 Feb 11.
PubMed PMID: 21311568; PubMed Central PMCID: PMC3097169.

9: Avnet S, Pallotta R, Perut F, Baldini N, Pittis MG, Saponari A, Lucarelli E,
Dozza B, Greggi T, Maraldi NM, Capanni C, Mattioli E, Columbaro M, Lattanzi G.
Osteoblasts from a mandibuloacral dysplasia patient induce human blood precursors
to differentiate into active osteoclasts. Biochim Biophys Acta. 2011
Jul;1812(7):711-8. doi: 10.1016/j.bbadis.2011.03.006. Epub 2011 Mar 16. PubMed
PMID: 21419220.

10: Lattanzi G. Prelamin A-mediated nuclear envelope dynamics in normal and
laminopathic cells. Biochem Soc Trans. 2011 Dec;39(6):1698-704. doi:
10.1042/BST20110657. Review. PubMed PMID: 22103510.