Lim Roderick

Country: Switzerland
Laboratory webpage
E-mail: roderick.lim@unibas.ch

Participation in Working Groups

  • WG1 - Biophysics of cell and tissue structure
  • WG2 - Structural analysis of biomolecules involved in mechanobiology
  • WG3 - New methodologies to study mechanobiology of cells and tissues
  • WG4 - Mechanobiological principles of rare and common diseases

Research Interests

The Lim Lab specializes in functional studies of biological machines, cells and tissues using atomic force microscopy (AFM). Recent breakthroughs include resolving the transport barrier of the nuclear pore complex by high-speed AFM (Sakiyama et al Nature Nanotechnology 2016) and the development of an AFM-based apparatus known as ARTIDIS for cancer diagnosis (Plodinec et al Nature Nanotechnology 2012). 

Technologies offered to other EuroCellNet participants

Atomic force microscopy 

Technologies sought from other EuroCellNet participants

FRET Sensors, intravital imaging, stable cell lines

Publications

Y. Sakiyama, A. Mazur, L.E. Kapinos and R.Y.H. Lim*, Spatiotemporal Dynamics of the Nuclear Pore Complex Transport Barrier Resolved by High-Speed Atomic Force Microscopy. Nature Nanotechnology, 11 719 (2016)

M. Plodinec* and R.Y.H. Lim, Nanomechanical characterization of living mammary tissues by atomic force microscopy. Methods in Molecular Biology, 1293, 231-46 (2015)

L.E. Kapinos, R.L. Schoch, R.S. Wagner, K.D. Schleicher and R.Y.H Lim*. Karyopherin-centric control of nuclear pores based on molecular occupancy and kinetic analysis of multivalent binding with FG-Nucleoporins. Biophys. J. 106 1751 (2014)

M. Plodinec, M. Loparic, C. A. Monnier, E. C. Obermann, R. Zanetti-Dallenbach, P. Oertle, J.T. Hyotyla, U. Aebi, M. Bentires-Alj, R. Y. H. Lim* and C-A. Schoenenberger, The Nanomechanical Signature of Breast Cancer. Nature Nanotechnology 7 757 (2012)

R.Y.H. Lim*, B. Fahrenkrog, J. Koser, K. Schwarz-Herion, J. Deng, and U. Aebi, Nanomechanical Basis of Selective Gating by the Nuclear Pore Complex, Science 318, 640 (2007)