Liovic Mirjana

Country: Slovenia
Laboratory webpage
E-mail: mirjana.liovic@mf.uni-lj.si

Participation in Working Groups

  • WG1 - Biophysics of cell and tissue structure
  • WG2 - Structural analysis of biomolecules involved in mechanobiology
  • WG3 - New methodologies to study mechanobiology of cells and tissues
  • WG4 - Mechanobiological principles of rare and common diseases

Research Interests

My current research interests span:

- regenerative medicine - currently we are developing advanced wound care products for chronic wounds such as diabetic foot, venous leg ulcers, skin burns and eye ulcerations; development of new therapy delivery systems for skin; basic research on mesenchyaml stem cells of the dental follicle and tooth pulp. These are the prime goal of my recently established biotech company - AdriaBio (https://adriabio.com) - Research and/or business collaborations are welcome!

- molecular medicine -  basic research regarding the function of the intermediate filament cytoskeleton and associate proteins, also in conjunction with human diseases; interdisciplinary studies on glioblastoma, identification of new markers, their potential use for more accurate diagnostics and efficient therapy: development of a breast cancer vaccine

Technologies offered to other EuroCellNet participants

Cell reprogramming - iPSC cell lines generation

Crispr/Cas9 genome editing

3D cell culturing

Drug screening

Cell culturing and testing (metabolic test, migration test, clonogenic test, permeability test)

Microscopy + live cell imaging

Optical tweezers

+ general techniques such as PCR, QPCR, microarray, protein expression and biochemistry, size exclusion chromatography

Technologies sought from other EuroCellNet participants

Looking for potential new research and/or business collaborations on a variety of topics, please feel free to make suggestions

Publications

Archaeosomes can efficiently deliver different types of cargo into epithelial cells grown in vitro.

Zavec AB, Ota A, Zupancic T, Komel R, Ulrih NP, Liovic M.

J Biotechnol. 2014 Dec 20;192 Pt A:130-5.

Intestinal cell barrier function in vitro is severely compromised by keratin 8 and 18 mutations identified in patients with inflammatory bowel disease.

Zupancic T, Stojan J, Lane EB, Komel R, Bedina-Zavec A, Liovic M.

PLoS One. 2014 Jun 10;9(6):e99398.

Inclusion bodies as potential vehicles for recombinant protein delivery into epithelial cells.

Liovic M, Ozir M, Zavec AB, Peternel S, Komel R, Zupancic T.

Microb Cell Fact. 2012 May 24;11:67.

Chemical chaperones protect epidermolysis bullosa simplex keratinocytes from heat stress-induced keratin aggregation: involvement of heat shock proteins and MAP kinases.

Chamcheu JC, Navsaria H, Pihl-Lundin I, Liovic M, Vahlquist A, Törmä H.

J Invest Dermatol. 2011 Aug;131(8):1684-91.

Severe keratin 5 and 14 mutations induce down-regulation of junction proteins in keratinocytes.

Liovic M, D'Alessandro M, Tomic-Canic M, Bolshakov VN, Coats SE, Lane EB.

Exp Cell Res. 2009 Oct 15;315(17):2995-3003.