My laboratory is focused in understanding the role of dermal stem cells in skin homeostasis and wound healing.This research led us into Schwann cells, pericytes, and the genes controlling their implication in succesful regeneration vs scar/fibrotic formation. Since we are cell biologists and tissue engineers based in a University Hospital, we also do tissue engineering with a main focus on skeletal muscle, but we have been active in engineering skin, blood vessels, peripheral nerves and bone tissue constructs of various kinds and also in pursuing their clinical application in diverse models of disease.
We are experts in stem cell isolation, 3D culture, differentiation, characterization, interaction with biomaterials and engineering of tissue constructs.
We also work on a daily basis with transgenic mouse lines to perform cell lineage tracing of the desired lineages.We have plenty of experience in characterizing stem cell function both in vitro and in vivo.
We have a preclinical skin wound model that we are currently expanding to different mouse strains so that we can trace the behaviour of particular cell lineages in response to wounding.
Finally, we are active in understanding the role of stem cell depletion in tissue aging and we are characterizing an aged mouse model of fragility with regard functional status of stem cells in the skin and muscle.
We are interested in understanding the mechanobiology underlying wound chronification and also in skeletal muscle diseases. Also in the balance of regeneration vs fibrosis. For this purpose we joined this network in the hope that people from an engineering background would help us approach these key issues, in skin, in muscle or in both. Specifically, the role of focal adhesions in chronic wounds is something that we are seeking to explore in the next year since there is an interesting link of FAK with the healing vs fibrosis balance and we think we have the right tools to understand this phenomenon better from the stem cell point of view. In the skeletal muscle, we have developed a 3D in vitro model that undergoes fatty degeneration (resembling the aged muscle phenotype in sarcopenia and also in degenerative disease) and we would like to understand the complex interactions of pulsating muscle bundles with ECM and the role of mechanical force in this in vitro muscle degeneration model.
Hair follicle-containing punch grafts accelerate chronic ulcer healing: A randomized controlled trial. Martínez ML, Escario E, Poblet E, Sánchez D, Buchón FF, Izeta A, Jimenez F. J Am Acad Dermatol. 2016 Nov;75(5):1007-1014. doi: 10.1016/j.jaad.2016.02.1161.
Identification and Characterization of the Dermal Panniculus Carnosus Muscle Stem Cells. Naldaiz-Gastesi N, Goicoechea M, Alonso-Martín S, Aiastui A, López-Mayorga M, García-Belda P, Lacalle J, San José C, Araúzo-Bravo MJ, Trouilh L, Anton-Leberre V, Herrero D, Matheu A, Bernad A, García-Verdugo JM, Carvajal JJ, Relaix F, Lopez de Munain A, García-Parra P, Izeta A. Stem Cell Reports. 2016 Sep 13;7(3):411-24. doi: 10.1016/j.stemcr.2016.08.002.
Neural-competent cells of adult human dermis belong to the Schwann lineage. Etxaniz U, Pérez-San Vicente A, Gago-López N, García-Dominguez M, Iribar H, Aduriz A, Pérez-López V, Burgoa I, Irizar H, Muñoz-Culla M, Vallejo-Illarramendi A, Leis O, Matheu A, Martín AG, Otaegui D, López-Mato MP, Gutiérrez-Rivera A, MacLellan R, Izeta A. Stem Cell Reports. 2014 Nov 11;3(5):774-88. doi: 10.1016/j.stemcr.2014.09.009.
Murine muscle engineered from dermal precursors: an in vitro model for skeletal muscle generation, degeneration, and fatty infiltration. García-Parra P, Naldaiz-Gastesi N, Maroto M, Padín JF, Goicoechea M, Aiastui A, Fernández-Morales JC, García-Belda P, Lacalle J, Álava JI, García-Verdugo JM, García AG, Izeta A, López de Munain A. Tissue Eng Part C Methods. 2014 Jan;20(1):28-41. doi: 10.1089/ten.TEC.2013.0146.
A pilot clinical study of hair grafting in chronic leg ulcers. Jiménez F, Garde C, Poblet E, Jimeno B, Ortiz J, Martínez ML, Gutiérrez-Rivera A, Pérez-López V, Etxaniz U, Naveda C, Higuera JL, Egüés N, Escario E, Izeta A. Wound Repair Regen. 2012 Nov-Dec;20(6):806-14. doi: 10.1111/j.1524-475X.2012.00846.x.
9-11 September 2019, Trnava, Slovakia