A-type lamins are nuclear envelope proteins that maintain mechanical stability of the nucleus and communicate the nucleus with the cytoskeleton and the plasma membrane. These proteins are linked to the regulation of the cytoskeleton, signal transduction, higher-order chromatin organization, DNA repair and replication, gene transcription, nuclear positioning, and cell proliferation, differentiation and migration. Although there is increasing knowing about A-type lamins functions in a variety of cell types, its role in the immune system is almost unknown. Among other immune cells, T-cells and some innate immune cells play central roles in orchestrating the protection against numerous and extremely diverse microbial pathogens and have acquired increased relevance in the origin and amelioration of chronic inflammatory diseases. My laboratory is interested in understanding the role of A-type lamins in adaptive and innate immune responses against pathogen infections and chronic inflammatory disorders not only from the cellular point of view but also from the molecular effect that A-lamins may have in the diverse cells types of the immune system.
We have expertise in different in vivo and in vitro models to study innate and adaptive immune responses including pathogen infections and inflammatory chronic diseases.
We are interested in high-throughput screening techniques as ChIPseq, RNAseq and Proteomics to understand the global changes that A-type lamins may be controlling in immune cells. We are also interested in microscopy techniques to understand the effect of nuclear envelope proteins in the behavior of the immune cells in the tissues in live mice . Finally, we are interested in knowing the specific role of the mechanotransduction in the importance of A-type lamins in the cells of the immune system.