Bour Petr

Country: Czech Republic
Laboratory webpage
E-mail: petr.bour@uochb.cas.cz

Participation in Working Groups

  • WG2 - Structural analysis of biomolecules involved in mechanobiology
  • WG3 - New methodologies to study mechanobiology of cells and tissues

Research Interests

Spectroscopy, imaging, interpretation of molecular spectra, molecular modelling.

In this project: peptide and protein conformation and interactions, neurodegenerative deseases, amyloydal fibrils, peptide mimetics, spectroscopic and imaging labels.

Technologies offered to other EuroCellNet participants

Computational chemistry (quantum, molecular dynamics), know how and limited hardware.

Organic chemistry, synthesis of model peptides.

Spectroscopies of (vibrational) circular dichroism and Raman optical activity.

Technologies sought from other EuroCellNet participants

Living cell models, imaging (microscopic) techniques, test of biological activity of symthetic/modified peptides.

Publications

[] Šugar, J.; Bouř, P. J.Raman. Spectrosc. 2016, “Quantitative analysis of sugar composition in honey using 532-nm excitation Raman and Raman optical activity spectra.”

DOI: 10.1002/jrs.4960

[1] Kessler, J.; Kapitán, J.; Bouř, P. J. Phys. Chem. Lett. 2015, 6 (16), 3314-3319. “First-principles predictions of vibrational Raman optical activity of globular proteins.”

DOI: 10.1021/acs.jpclett.5b01500,

[] Pour, S. O.; Rocks, L.; Faulds, K.; Graham, D.; Parchaňský, V.; Bouř, P.; Blanch, E. W. Nature Chem. 2015, 7, 591–596. “Through-space transfer of chiral information mediated by a plasmonic nanomaterial.”

DOI:10.1038/nchem.2280

[] Parchaňský, V.; Kapitán, J.; Bouř, P. RSC Adv. 2014, 4, 57125-57136. “Inspecting chiral molecules by Raman optical activity spectroscopy.“

[] Kessler, J.; Keiderling, T. A.; Bouř, P. J. Phys. Chem. B 2014, 118, 6937-6945. „Arrangement of Fibril Side Chains Studied by Molecular Dynamics and Simulated Infrared and Vibrational Circular Dichroism Spectra.”