Miettinen Susanna

Country: Finland
Laboratory webpage
E-mail: susanna.miettinen@uta.fi

Participation in Working Groups

  • WG1 - Biophysics of cell and tissue structure
  • WG2 - Structural analysis of biomolecules involved in mechanobiology
  • WG3 - New methodologies to study mechanobiology of cells and tissues
  • WG4 - Mechanobiological principles of rare and common diseases

Research Interests

  • Mesenchymal stem cell characterization and basic stem cell biology
  • Preservation of growth, multipotent differentiation capacity and functionality
  • Molecular mechanisms of stem cell differentiation, cell attachment, cell morphology, migration
  • Bone and adipose tissue engineering
  • Tissue engineering in epithelial applications
  • Effect of biomaterials (composition, structure, topography, drug release), mechanical loading (vibration and stretching) and electrical stimulation on cells
  • Vascularization
  • Regulation of immunogenic and immunomodulatory properties of mesenchymal stem cells
  • Clinical cell therapy with mesenchymal stem cells (bone defects, incontinence, stroke)

Technologies offered to other EuroCellNet participants

We have expertise in stem cell biology, especially mesenchymal stem cells, tissue engineering, biomaterials, cell-biomaterial interactions, mechanical stimulation of cell cultures (for example vibration loading, cell stretching), signal transduction in stem cell differentiation, especially osteogenic and adipogenic differentiation.

Technologies sought from other EuroCellNet participants

We are interested in studying how cell adhesion and cytoskeletal arrangements affect stem cell behavior, i.e. proliferation, migration and differentiation. In addition we are interested in new methodologies to study mechanobiology of cells and tissues and how pathological conditions affect cells. Especially we would like to learn imaging techniques to analyze cell adhesion, cell migration and cytoskeletal arrangements on biomaterial surfaces.

Publications

1. Vanhatupa S, Ojansivu M, Autio R, Juntunen M, Miettinen S. Bone Morphogenetic Protein-2 Induces Donor-Dependent Osteogenic and Adipogenic Differentiation in Human Adipose Stem Cells. Stem Cells Transl Med. 2015 Dec;4(12):1391-402.

2. Ojansivu M, Vanhatupa S, Björkvik L, Häkkänen H, Kellomäki M, Autio R, Ihalainen JA, Hupa L, Miettinen S. Bioactive Glass Ions as Strong Enhancers of Osteogenic Differentiation in Human Adipose Stem Cells. Acta Biomater. 2015 Jul 15;21:190-203.

3. Sartoneva R, Haaparanta AM, Lahdes-Vasama T, Mannerström B, Kellomäki M, Salomäki M, Sándor GK, Suuronen R, Miettinen S, Haimi S. Characterizing and optimizing poly-L-lactide-co-e-caprolactone (PLCL) membranes for urothelium tissue engineering. J R Soc Interface. 2012 Dec 7;9(77):3444-54.

4. Sarkanen J-R, Kaila V, Lindroos B, Räty S, Kuokkanen H, Miettinen S and Ylikomi T. Human adipose tissue extract induces angiogenesis and adipogenesis in vitro. Tissue Eng Part A. 2012 Jan;18(1-2):17-25.

5. Tirkkonen L, Halonen H, Hyttinen J, Kuokkanen H, Sievänen H, Koivisto AM, Mannerström B, Sándor GK, Suuronen R, Miettinen S, Haimi S. The effects of vibration loading on adipose stem cell number, viability and differentiation towards bone-forming cells. J R Soc Interface. 2011 Dec 7;8(65):1736-47.