Trullas Ramon

Trullas Ramon Country: Spain
Laboratory webpage
E-mail: ramon.trullas@iibb.csic.es

Participation in Working Groups

  • WG3 - New methodologies to study mechanobiology of cells and tissues
  • WG4 - Mechanobiological principles of rare and common diseases

Research Interests

Molecular mechanisms of mitochondrial dynamics, transport and mitochodondrial DNA replication and release in neurodegenerative diseases

Technologies offered to other EuroCellNet participants

Digital PCR. Absolute quantification of DNA and RNA. In vivo cell imaging.

Technologies sought from other EuroCellNet participants

Superresolution microscopy. In vivo cell imaging

Publications

Clayton KB, Podlesniy P, Figueiro-Silva J, López-Doménech G, Benitez L, Enguita M, Abad MA, Soriano E, Trullas R. (2012) NP1 Regulates Neuronal Activity-Dependent Accumulation of Bax in Mitochondria and Mitochondrial Dynamics. Journal of Neuroscience. 32(4):1453-66.

López-Doménech G, Serrat R, Mirra S, D'Aniello S, Somorjai I, Abad A, Vitureira N, García-Arumí E, Alonso MT, Rodriguez-Prados M, Burgaya F, Andreu AL, García-Sancho J, Trullas R, Garcia-Fernàndez J, Soriano E. (2012). The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2. Nature Communications. 3:814. doi: 10.1038/ncomms1829.

Podlesniy P, Figueiro-Silva J, Llado A, Antonell A, Sanchez-Valle R, Alcolea D, Lleo A, Molinuevo JL, Serra N, Trullas R. (2013). Low cerebrospinal fluid concentration of mitochondrial DNA in preclinical Alzheimer disease. Annals of Neurology.4(5):655-68. doi: 10.1002/ana.23955. Epub 2013 Sep 4.

Lamarca A, Gella A, Martiañez T, Segura M, Figueiro-Silva J, Grijota-Martinez C, Trullas R, Casals N. (2014). Uridine 5'-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation.PLoS One.Jun 6;9(6):e98998. doi: 10.1371/journal.pone.0098998. eCollection 2014.

Figueiro-Silva J, Gruart A, Clayton KB, Podlesniy P, Abad MA, Gasull X, Delgado-García JM, Trullas R. (2015). Neuronal pentraxin 1 negatively regulates excitatory synapse density and synaptic plasticity. Journal of Neuroscience. 8;35(14):5504-21.

Podlesniy P, Llorens F, Golanska E, Sikorska B, Liberski P, Zerr I, Trullas R. (2016). Mitochondrial DNA differentiates Alzheimer's disease from Creutzfeldt-Jakob disease. Alzheimer’s & Dementia.12(5):546-55. doi: 10.1016/j.jalz.2015.12.011.

Podlesniy P, Vilas D, Taylor P, Shaw LM, Tolosa E, Trullas R. (2016). Mitochondrial DNA in CSF distinguishes LRRK2 from idiopathic Parkinson's disease. Neurobiology of Disease. 94:10-7. doi: 10.1016/j.nbd.2016.05.019. Epub 2016 May 31.