Mladenovic Djordjevic Aleksandra

Country: Serbia
Laboratory webpage

Participation in Working Groups

  • WG4 - Mechanobiological principles of rare and common diseases

Research Interests

-brain ageing
-synaptic plasticity
-neurodegeneration and neurodegenerative disease (especially Alzheimer’s disease)
-cholesterol metabolism
-interventions that delay ageing and age-related disorders (dietary restriction, omega-3 fatty acid, metformin...)

Technologies offered to other EuroCellNet participants

-Cell culture (primary neuronal culture, cell line)
-In vivo models of neurodegenerative disease (6-OHDA model of Parkinson’s disease, 5xFAD model of Alzheimer disease) short and long term dietary restriction model
-RNA, DNA, protein isolation, PCR, RT-PCR, western blot, immunocytochemistry and immunohistochemistry, brain structure isolation, stereotactic surgery

Technologies sought from other EuroCellNet participants

-Interesting in any technique that would enable better understanding of neurodegenerative processes


1. Smiljanic K, Pesic V, Mladenovic-Djordjevic A, Pavkovic Z, Brkic M, Ruzdijic S, Kanazir S. Long-term dietary restriction differentially affects the expression of BDNF and its receptors in the cortex and hippocampus of middle-aged and aged male rats. Biogerontology 2015; 16:71-83.
2. Mladenovic Djordjevic A, Perovic M, Smiljanic K, Todorovic S, Tesic V, Ruzdijic S, Kanazir S. The effects of dietary restriction and aging on amyloid precursor protein and presenilin-1 mRNA and protein expression in rat brain. Neuroreport 2014; 25:398-403.
3. Smiljanic K, Vanmierlo T, Mladenovic Djordjevic A, Perovic M, Ivkovic S, Lütjohann D, Kanazir S. Cholesterol metabolism changes under long-term dietary restrictions while the cholesterol homeostasis remains unaffected in the cortex and hippocampus of aging rats. AGE 2014; Doi: 10.1007/s11357-014-9654-z
7. Mladenovic Djordjevic A, Perovic M, Tesic V, Tanic N, Rakic Lj, Ruzdijic S, Kanazir S. Long-term dietary restriction modulates the level of presynaptic proteins in the cortex and hippocampus of the agingrat. Neurochem Int. 2010; 56: 250-255.
8. Mladenovic Djordjevic A, Perovic M*, Smiljanic K, Tanic N, Rakic L, Ruzdijic S, Kanazir S. Expression of cholesterol homeostasis genes in the brain of the male rat is affected by age and dietary restriction. Biogerontology, 2009; 10: 735-745. (*equal contribution)


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