We study the nuclear lamina and nuclear organization. Our main model animal is C. elegans
The laboratory has an advanced microinjection system, a stretching device, Olympus IX70, Zeiss Axioplan II and Olympus stereo microscope, several light stereo microscopes, gradient plate PCR machine, a BioRad gene gun (bombardment) machine. The Institute of Life Sciences has common equipment at our disposal including three high quality confocal microscopes and a Technai 12 electron microscope. The DNA Analyses Centre provides access to an in-house microarray printing facility, next generation sequencing , an ABI 3700 DNA Analyzer, robotic systems and a Fluidigm with C1. Recombinant protein production, purification and analysis services are also available. Other large resources available include a 2 QExactivePlus Orbitrap (Thermo) coupled with the easyspraynanoLC system (Dionex) mass spectrometer for proteomics analyses, BD FACSAria™ III sorter multicolor performance and FACScalibur with a 488 laser, a Phosphoimager and Biacore .
The mechanical properties of nuclei in health and disease states
Regulation of cell metabolism by the nuclear lamina
The mechanistic bases of laminopathic diseases
9-11 September 2019, Trnava, Slovakia