Hebrew University of Jerusalem



Givat Ram
91904 Jerusalem

Phone: +97226585981



Yosef Gruenbaum
Phone: +97226585995
Email: gru@vms.huji.ac.il

Involved in

  • WG1 - Biophysics of cell and tissue structure
  • WG2 - Structural analysis of biomolecules involved in mechanobiology
  • WG3 - New methodologies to study mechanobiology of cells and tissues
  • WG4 - Mechanobiological principles of rare and common diseases

General description research focus

We study the nuclear lamina and nuclear organization. Our main model animal is C. elegans

Imaging technologies available

  • Laser Scanning Confocal Microscopy (LSM / CLSM)
  • Deconvolution Widefield Microscopy
  • Electron Microscopy

Equipment available

The laboratory has an advanced microinjection system, a stretching device, Olympus IX70, Zeiss Axioplan II and Olympus stereo microscope, several  light stereo microscopes, gradient plate PCR machine, a BioRad gene gun (bombardment) machine.  The Institute of Life Sciences has common equipment at our disposal including three high quality confocal microscopes  and a Technai 12 electron microscope. The DNA Analyses Centre  provides access to an in-house microarray printing facility, next generation sequencing , an ABI 3700 DNA Analyzer, robotic systems and a Fluidigm with C1. Recombinant protein production, purification and analysis services are also available. Other large resources available include a 2 QExactivePlus Orbitrap (Thermo) coupled with the easyspraynanoLC system (Dionex) mass spectrometer for proteomics analyses, BD FACSAria™ III sorter multicolor performance and FACScalibur with a 488 laser, a Phosphoimager and Biacore . 

Expertise support provided to users


Research topics directly investigated in research group

The mechanical properties of nuclei in health and disease states

Regulation of cell metabolism by the nuclear lamina

The mechanistic bases of laminopathic diseases

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