Structural networks that connect the extracellular matrix and cell surfaces through the cytoskeleton with the nucleoskeleton govern cell, tissue and organ integrity. Besides their structural roles, these networks participate in a multitude of fundamental functions, e.g. regulating signal- and mechano-transduction, cytoplasmic transport, sequestering biomolecules, maintaining genome organization and promoting meiosis. Mutations in the building blocks of these networks frequently lead to devastating diseases. The pathogenesis of these diseases is far from being understood and requires a wide interdisciplinary approach that is distinct from the individual research schemes. Based on capacity building measures, coordinated networking and educative activities and interactions with business partners and European research infrastructures, the EuroCellNet Action aims to develop an orchestrated multinational activity grid, organized in four Working Groups:
The Action targets researchers from molecular and cell biology, genetics, biophysics, structural biology, mechanobiology, neurobiology, developmental biology, pathology, and translational medicine. The Action will also develop new bridging and educative activities, and provide the scientists with a unifying dedicated website with on-line tools facilitating the interactions and exchange of information.
Areas of Expertise Relevant for the Action
To achieve the main objective, the following specific objectives shall be accomplished:
1) The person who is interested in joining the WG completes an online application:
2) Completed form will be sent to the WG´s leader, WG leader will accept or reject an application.
3) The Core Group will approve or disapprove the request.
4) The Chair will inform the applicant
1) The organizer of each activity prepare a list of participants to be reimbursed
2) The organizer discusses with the leader of the relevant Work Group(s) the list
3) The list is submitted for a formal check to the office of the Action chair
4) The Chair submits the list for MC online vote or a vote at the MC meeting
5) At ach of the steps of this procedure, in addition to the standard COST requirements, preference should be given to participants from countries with lowest recorded participation in EuroCellnet Action history
1) An open call for all future activities with online forms is run whenever appropriate, typically, when discussing the next Grant periods.
2) Each MC Member, MC Substitute, and WG Member can propose future activities, discuss them primarily within relevant Work groups.
3) Each proposer is asked to explain the scientific content, relevance to the programs of the WGs, and which Action deliverables and outcomes would be achieved when granted.
4) All MC members are given the complete list of Activities proposed, and they evaluate them online for two criteria: 1) scientific excellence and 2) relevance to EuroCellnet aims.
5) Once the data is collected, the Work Groups discuss the outcome and give recommendation if needed to the Chair of the Action, and the Core group discusses the outcome of this MC evaluation of proposals, and proposes the budget and working plan for the next GP. This draft is presented to the entire MC and pre-approved by an online vote.
6) The Chair of Action will discuss the plans with the COST Scientific Officer, changes are adopted depending on SO suggestions and requests. After this, the Core Group finalizes the Work and Budget plans and submits if for final online approval to the entire MC.
1) Any MC Member can propose a dissemination activity at a meeting/congress together with a proposal for the Eurocellnet COST disseminator. For each Grant Period, a call for dissemination activity is held by the Action with two disseminators per each Grant Period maximum (according to the COST Vademecum).
2) The Action lead disseminator, who was elected at the beginning of the Action by MC, and the Core Group evaluate the proposal, and inform the Chair about the feasibility of the proposal regarding the COST Action aims and rules.
3) The Chair initiates an MC vote on the proposal based on the Core Group statement.
The proposals are currently being evaluated.